DAMASCUS, May 26 (Xinhua) -- At least five people were killed and 43 others wounded on Saturday when a car bomb went off in the rebel-held city of Idlib in northwestern Syria, a monitor group reported.

The big explosion rocked the 30-Street in Idlib, causing heavy smoke and dust in the area, said the Syrian Observatory for Human Rights.

The death toll could likely rise as many people were in critical conditions, the London-based watchdog added.

The explosion came just two weeks after a previous one targeting the city, which killed 28 people, including militants with the al-Qaida-linked Levant Liberation Committee.

Idlib has for long been under the control of various rebel groups, as it is the main destination for the rebels who recently evacuated the areas around the capital Damascus and in central Syria after reaching deals with the government.

After being jam-packed with militants, Idlib has witnessed rising infighting between rebel groups, particularly attacks against the al-Qaida-linked ones.